Endocrine Abstracts

Introduction: Previous audits demonstrated low bone mineral density (BMD) in adolescent patients with hormone deficiencies. We wanted to ascertain if gender had any relationship with the development of low BMD.Method: A retrospective analysis of 42 Transitional clinic patients who underwent DEXA scanning was made using case notes and hospital systems. Follow-up data was gathered as previous audit of 25 transitional patients had shown a significant number...

Introduction: According to NICE: adults receiving growth hormone (GH) treatment, IGF1 levels should reach therapeutic range by 9 months. Patients are reviewed at 1, 3, 6, 9, 12 months and 6 months thereafter in our clinics. GH dose is titrated by 0.1 mg each visit. This work aims to compare the time it takes to get the IGF1 in range, between adults and adolescent patients attending our specialist regional clinics.Method: We performed a retrospective audi...

Introduction: Previous audits demonstrated low bone mineral density (BMD) in adolescent patients with hormone deficiencies. We wanted to ascertain if gender had any relationship with the development of low BMD.Method: A retrospective analysis of 42 transitional clinic patients who underwent DEXA scanning was made using case notes and hospital systems. Follow-up data was gathered as previous audit of 25 transitional patients had shown a significant number...

Introduction: According to NICE: adults receiving GH treatment, IGF1 levels should reach therapeutic range by 9 months. Patients are reviewed at 1, 3, 6, 9, 12 months and 6 months thereafter in our clinics. GH dose is titrated by 0.1 mg each visit. This work aims to compare the time it takes to get the IGF1 in range, between adults and adolescent patients attending our specialist regional clinics.Method: We performed a retrospective audit of 20 patients ...

A 28-year-man originally from Africa presented with short stature. His height at first clinic visit was 128 cm and there was no family history of short stature. He had pale complexion, lack of facial/body hair and under-developed secondary sexual characteristics consistent with morphology of hypopituitaric dwarfism. Insulin stress test with adequate hypoglycaemia<2.2 mmol/l confirmed flat growth hormone (GH) response (peak <0.5 mU/l) and inadequate cortisol response (p...

Objectives: To collect qualitative and quantitative information on the burden of adult growth hormone deficiency (AGHD) diagnostic tests for the patient.Methods: A survey was published on The Pituitary Foundation’s website and social media pages; respondents completed it online using SmartSurvey over period of two months (October-November 2021). 105 respondents took the survey, with 9 screened out after the first question because they had never take...

Background: NF1 and MEN2 are rare conditions known to associate with bilateral phaeochromochtomas. We describe, with relevant associated radiology, a NF1 patient developing a series of neuroendocrine tumours including bilateral phaeochromocytomas.Clinical case: A 39-year-old lady presented with long standing episodic abdominal pain, diarrhoea, palpitation and sweating. Past history includes first arch syndrome and NF1 at teens and total thyroidectomy for...

An 18 year old lady was seen in endocrine clinic in October 2004 with 10 month history of polyuria, polydypsia and lethargy. Previous medical history includes Graves thyrotoxicosis which is treated with carbimazole.Clinical examination was unremarkable.Investigations and management: Urine osmolality −84 mosmol (250–750), serum osmolality −290 mosmol (288–298), full blood count, fasting glucose, renal, liver fu...

Background: Patient experience is a crucial part of patient care, but is not systematically assessed. In light of this we performed a UK-wide survey to understand the care experiences of patients with pituitary conditions over the preceding three years.Methods: In collaboration with patients and pituitary experts a web-based survey was designed, aimed at patients 18yrs and over. Specific topics included: assessment of information provision, communication...

Introduction: Adult growth hormone deficiency (AGHD) is associated with target organ insensitivity to parathyroid hormone (PTH) and abnormal PTH circadian rhythm. In aging women with established osteoporosis, GH and insulin like growth factor -1 (IGF-1) concentrations are low and administration of GH has been shown to increase bone turnover and bone mineral density (BMD), but the mechanisms remain unclear. Consequently we investigated the effects of declining GH and IGF-1 conc...